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CELL DEATH, PARP-1-DEPENDENT
Descriptors Found:
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DeCS
Descriptor
English
:
Parthanatos
Descriptor
Spanish
:
Parthanatos
Descriptor
Portuguese
:
Parthanatos
Synonyms
English
:
Cell Death, PARP-1-Dependent
Cell Death, PARP-Dependent
PARP 1 Dependent Cell Death
PARP Dependent Cell Death
PARP-1-Dependent Cell Death
PARP-Dependent Cell Death
Tree Number:
G04.146.954.750
Definition
English
:
A type of
regulated cell death
initiated by hyperactivation of POLY (ADP-RIBOSE) POLYMERASE-1 (PARP-1) as a consequence of
DNA DAMAGE
;
OXIDATIVE STRESS
;
HYPOXIA
;
HYPOGLYCEMIA
; or
INFLAMMATION
. This leads to
DNA FRAGMENTATION
and
CHROMATIN
condensation.
History Note
English
:
2020
Allowable Qualifiers
English
:
DE
drug effects
GE
genetics
IM
immunology
PH
physiology
RE
radiation effects
Record Number:
59187
Unique Identifier:
D000079323
Occurrence in VHL
:
Similar:
DeCS